Meta-analysis of genetic association studies under different inheritance models using data reported as merged genotypes.

Abstract excerpt

Meta-analysis of population-based genetic association studies is often challenged by obstacles associated with the underlying inheritance model. For a simple genetic variant with two alleles, a recessive, dominant or co-dominant model is typically assumed. In the absence of a strong biological rationale for a particular inheritance model, a recently suggested inheritance-model-free approach can be implemented. To...

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