Article
The choice of a genetic model in the meta-analysis of molecular association studies.
International journal of epidemiology - 1 Dec 2005
Minelli Cosetta, Thompson John R, Abrams Keith R, Thakkinstian Ammarin, Attia John
Abstract excerpt
BACKGROUND: To evaluate gene-disease associations, genetic epidemiologists collect information on the disease risk in subjects with different genotypes (for a bi-allelic polymorphism: gg, Gg, GG). Meta-analyses of such studies usually reduce the problem to a single comparison, either by performing two separate pairwise comparisons or by assuming a specific underlying genetic model (recessive, co-dominant,...
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