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Article

Modifiers and subtype-specific analyses in whole-genome association studies: a likelihood framework.

Human heredity - 1 Jan 2011

Lee Phil H, Bergen Sarah E, Perlis Roy H, Sullivan Patrick F, Sklar Pamela, Smoller Jordan W, Purcell Shaun M

Abstract excerpt

OBJECTIVE: We propose new statistical methods for analyzing genetic case/control association data in which cases can be further classified into subtypes, for example, based on clinical features. The primary utility of our work is the ability to distinguish between subtype-specific and modifier effects of genetic variants within a single testing framework. METHODS: A range of disease/subtype causal models are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21849790
DOI: 10.1159/000327158
PMCID: PMC7077092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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