Article
Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis.
Arthritis and rheumatism - 1 Nov 2010
Keenan Brendan T, Chibnik Lori B, Cui Jing, Ding Bo, Padyukov Leonid, Kallberg Henrik, Bengtsson Camilla, Klareskog Lars, Alfredsson Lars, Karlson Elizabeth W
Abstract excerpt
OBJECTIVE: Glutathione S-transferase (GST) genes as well as heme oxygenase 1 gene (HMOX1) encode enzymes that detoxify carcinogens and protect against oxidative stress. This study was undertaken to examine the impact of gene-smoking interactions on susceptibility to rheumatoid arthritis (RA). METHODS: Caucasian patients with RA and matched control subjects (n = 549 each) were selected from the Nurses' Health...
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