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Article

Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans.

Arthritis and rheumatism - 1 Mar 2012

Mikuls Ted R, Levan Tricia, Gould Karen A, Yu Fang, Thiele Geoffrey M, Bynote Kimberly K, Conn Doyt, Jonas Beth L, Callahan Leigh F, Smith Edwin, Brasington Richard, Moreland Larry W, Reynolds Richard, Gaffo Angelo, Bridges S Louis

Abstract excerpt

OBJECTIVE: To examine whether polymorphisms in genes coding for drug-metabolizing enzymes (DMEs) have an impact on rheumatoid arthritis (RA) risk due to cigarette smoking in African Americans. METHODS: Smoking status was evaluated in African American patients with RA compared with non-RA controls, with smoking exposure categorized as heavy smoker (≥10 pack-years) versus never smoker/<10 pack-years. Individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21989592
DOI: 10.1002/art.33408
PMCID: PMC3272109

Genes

NAT2
GSTM1
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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