Article
Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione S-transferase in a cross-sectional study.
Arthritis research & therapy - 1 Jan 2010
Mikuls Ted R, Gould Karen A, Bynoté Kimberly K, Yu Fang, Levan Tricia D, Thiele Geoffrey M, Michaud Kaleb D, O'Dell James R, Reimold Andreas M, Hooker Roderick, Caplan Liron, Johnson Dannette S, Kerr Gail, Richards J Steuart, Cannon Grant W, Criswell Lindsey A, Noble Janelle A, Bridges S Louis, Hughes Laura, Gregersen Peter K
Abstract excerpt
INTRODUCTION: A deletion polymorphism in glutathione S-transferase Mu-1 (GSTM1-null) has previously been implicated to play a role in rheumatoid arthritis (RA) risk and progression, although no prior investigations have examined its associations with anticitrullinated protein antibody (ACPA) positivity. The purpose of this study was to examine the associations of GSTM1-null with ACPA positivity in RA and to...
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