Article

Structural variant selection for high-altitude adaptation using single-molecule long-read sequencing

2021-03-27

Abstract excerpt

Structural variants (SVs) can be important drivers of human adaptation with strong effects, but previous studies have focused primarily on common variants with weak effects. Here, we used large-scale single-molecule long-read sequencing of 320 Tibetan and Han samples, to show that SVs are key drivers of selection under high-altitude adaptation. We expand the landscape of global SVs, apply robust models of selectio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52d87cb7-bc02-563e-b78b-42c2c5b920c3
DOI: 10.1101/2021.03.27.436702

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural variant selection for high-altitude adaptation using single-molecule long-read sequencingDOI 10.1101/2021.03.27.436702Read

Tibetan near-complete pangenome reveals complex variants underlying high-altitude adaptationSemantic proximity Read

Characterization of Structural Variation in Tibetans Reveals New Evidence of High-altitude Adaptation and IntrogressionSemantic proximity Read

Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation.Semantic proximity Read

Sequencing of 50 human exomes reveals adaptation to high altitude.Semantic proximity Read

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptationSemantic proximity Read

<i>De novo</i> assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptationSemantic proximity Read

Structural variants in Chinese population and their impact on phenotypes, diseases and population adaptationSemantic proximity Read

Structural variation across 138,134 samples in the TOPMed consortiumSemantic proximity Read

An integrated map of genetic variation from 1,092 human genomes.Semantic proximity Read

Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals cis-regulatory Contributions to High-altitude Adaptation in Tibetan PigsSemantic proximity Read

Structural variation across 138,134 samples in the TOPMed consortiumSemantic proximity Read

Genetic analysis of cold tolerance and high-altitude adaptation in Gannan indigenous Tibetan sheep through genome-wide scans.Semantic proximity Read