Article
Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia.
Genome research - 1 Aug 2014
Gou Xiao, Wang Zhen, Li Ning, Qiu Feng, Xu Ze, Yan Dawei, Yang Shuli, Jia Jia, Kong Xiaoyan, Wei Zehui, Lu Shaoxiong, Lian Linsheng, Wu Changxin, Wang Xueyan, Li Guozhi, Ma Teng, Jiang Qiang, Zhao Xue, Yang Jiaqiang, Liu Baohong, Wei Dongkai, Li Hong, Yang Jianfa, Yan Yulin, Zhao Guiying, Dong Xinxing, Li Mingli, Deng Weidong, Leng Jing, Wei Chaochun, Wang Chuan, Mao Huaming, Zhang Hao, Ding Guohui, Li Yixue
Abstract excerpt
The hypoxic environment imposes severe selective pressure on species living at high altitude. To understand the genetic bases of adaptation to high altitude in dogs, we performed whole-genome sequencing of 60 dogs including five breeds living at continuous altitudes along the Tibetan Plateau from 800 to 5100 m as well as one European breed. More than 150× sequencing coverage for each breed provides us with a...
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