Article

BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions

2025-04-19

Abstract excerpt

The β-secretase BACE1 has become a prime target in Alzheimer’s disease (AD) therapy, because it drives the production of pathogenic amyloid β peptides. However, clinical trials with BACE1-targeting drugs were halted due to adverse effects on cognitive performance. We propose here that cognitive impairment by BACE1 inhibitors may be a corollary of a higher function of BACE1 related to proper sleep regulation. To ad...

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Literature Corpus work: 0f54afce-c233-5f3b-8c69-8f8099cb9753
DOI: 10.1101/2025.04.17.648898

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