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Article

BACE1 as an early biomarker and its relevance to risk factors for Alzheimer’s disease

22 Jul 2025

Abstract excerpt

While the β-secretase BACE1 is responsible for the rate-limiting initial step to generate amyloid-β (Aβ) peptides, BACE1 inhibitor clinical trials have been halted due to a lack of efficacy and/or safety concerns at symptomatic/prodromal stages of Alzheimer's disease (AD). These trials were often targeted at high levels of BACE1 inhibition (>70 %) and ended up with signs of mild cognitive worsening instead of...

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PMID: 40706761
DOI: 10.1016/j.brainresbull.2025.111475

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