Article
Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Apr 2013
Corbett Brian F, Leiser Steven C, Ling Huai-Ping, Nagy Reka, Breysse Nathalie, Zhang Xiaohong, Hazra Anupam, Brown Jon T, Randall Andrew D, Wood Andrew, Pangalos Menelas N, Reinhart Peter H, Chin Jeannie
Abstract excerpt
BACE1 is the rate-limiting enzyme that cleaves amyloid precursor protein (APP) to produce the amyloid β peptides that accumulate in Alzheimer's disease (AD). BACE1, which is elevated in AD patients and APP transgenic mice, also cleaves the β2-subunit of voltage-gated sodium channels (Navβ2). Although increased BACE1 levels are associated with Navβ2 cleavage in AD patients, whether Navβ2 cleavage occurs in APP...
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