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Article

Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Apr 2013

Corbett Brian F, Leiser Steven C, Ling Huai-Ping, Nagy Reka, Breysse Nathalie, Zhang Xiaohong, Hazra Anupam, Brown Jon T, Randall Andrew D, Wood Andrew, Pangalos Menelas N, Reinhart Peter H, Chin Jeannie

Abstract excerpt

BACE1 is the rate-limiting enzyme that cleaves amyloid precursor protein (APP) to produce the amyloid β peptides that accumulate in Alzheimer's disease (AD). BACE1, which is elevated in AD patients and APP transgenic mice, also cleaves the β2-subunit of voltage-gated sodium channels (Navβ2). Alth...

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Source

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Identifiers

PMID: 23595759
DOI: 10.1523/JNEUROSCI.2325-12.2013
PMCID: PMC6618875

Genes

APP
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23595759-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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