Article
The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity.
Neuron - 1 Mar 1995
Chapman P F, Frenguelli B G, Smith A, Chen C M, Silva A J
Abstract excerpt
The alpha-Ca2+/calmodulin kinase II (alpha CaMKII) is required for long-term potentiation in the CA1 region of the hippocampus. Here, we report that this kinase also has a crucial role in presynaptic plasticity. Paired-pulse facilitation is blunted in the CA1 region of mice heterozygous for a tar...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Calcium-Calmodulin-Dependent Protein Kinases
- Crosses, Genetic
- Electric Stimulation
- Evoked Potentials
- Heterozygote
- Hippocampus
- In Vitro Techniques
- Long-Term Potentiation
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Mutation
- Neuronal Plasticity
- Patch-Clamp Techniques
- Pyramidal Cells
- Synapses