Article
Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinoma.
Digestion - 1 Jan 2010
Kato Yukihiro, Yashiro Masakazu, Noda Satoru, Kashiwagi Shinichiro, Matsuoka Junko, Fuyuhiro Yuhiko, Doi Yosuke, Hirakawa Kosei
Abstract excerpt
BACKGROUND/AIMS: Gastric cancers are characterized by a heterogeneously hypoxic environment. Hypoxia might stimulate the malignant potential of cancer cells. The purpose of our study was to clarify the significance of hypoxia in gastric carcinoma by evaluating the expression of a hypoxic marker, namely carbonic anhydrase-9 (CA-9). METHODS: A total of 265 patients who had undergone a resection of the primary tumor...
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