3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma.

doi:10.1038/s41598-017-04732-3

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Article

3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma.

Scientific reports - 30 Jun 2017

Hua Kuo-Tai, Liu Yu-Fan, Hsu Chia-Lang, Cheng Tsu-Yao, Yang Ching-Yao, Chang Jeng-Shou, Lee Wei-Jiunn, Hsiao Michael, Juan Hsueh-Fen, Chien Ming-Hsien, Yang Shun-Fa

Abstract excerpt

Carbonic anhydrase IX (CA9) expression level has been considered as a poor prognostic factor in hepatocellular carcinoma (HCC) patients. However, the judging criteria of CA9 level is hard to define for potential clinical applications. Unlike CA9 expression level, CA9 polymorphism is poorly documented in HCC. Here, we found that people carry A allele at CA9 rs1048638, a 3'UTR SNP, has higher risk of HCC....

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PMID: 28667334
DOI: 10.1038/s41598-017-04732-3
PMCID: PMC5493636

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