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Article

Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer

8 Dec 2015

Abstract excerpt

Solid tumors are often exposed to hypoxia. Hypoxia inducible factor (HIF)-1α upregulates numerous target genes associated with the malignant behavior of hypoxic cancer cells. A member of the angiopoietin family, angiopoietin-like protein 4 (ANGPTL4) is a hypoxia-inducible gene. The present study aimed to clarify whether ANGPTL4 is regulated by HIF-1α in gastric cancer cells. The study also assessed whether...

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PMID: 26893686
DOI: 10.3892/ol.2015.4011

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