Article
Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.
Cancer research - 15 Jul 2014
Adams Clare M, Eischen Christine M
Abstract excerpt
Inactivation of p53, the master regulator of cellular stress and damage signals, often allows cells that should die or senesce to live. Loss of Dicer, an RNase III-like enzyme critical in microRNA biogenesis, causes embryonic lethality and activation of the p53 pathway. Several nonhematopoietic cell types that contain inactivated p53 have been shown to survive Dicer deletion, suggesting that p53 loss may protect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.