Article

Dicer-to-Argonaute switch controls biogenesis of oncogenic miRNA

2021-08-31

Abstract excerpt

miRNAs are post-transcriptional regulators of gene expression, controlling biological processes from development to pathogenesis. We asked whether the reshaped functional miRNA landscape in cancers is driven by altered transcription of its precursors, or altered biogenesis and maturation of miRNAs. Integrated analysis of genomic and transcriptomic data in 9,111 samples across 10 cancer types and healthy tissues re...

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Literature Corpus work: 40b3b1c6-fd30-5832-80c1-7f6fe221c427
DOI: 10.1101/2021.08.30.458145

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