Article

<i>DICER1</i> syndrome mutations lead to a gain of 3p-miRNA function, HERVH activity and increased metastatic potential

2025-12-16

Abstract excerpt

The DICER1 gene is mutated in cancer, including DICER1 syndrome, a rare tumour predisposition syndrome. Cancer-associated hotspot mutations have been reported in both catalytic domains of DICER1 and are predicted to disrupt miRNA biogenesis. To understand how these hotspot mutations contribute to cancer development, we have generated cell lines harbouring single amino acid substitutions within the catalytic RNase...

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Literature Corpus work: e0053c72-bc59-59d4-8181-8a25f4ed706b
DOI: 10.64898/2025.12.16.694338

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