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Article

Bim is a suppressor of Myc-induced mouse B cell leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2004

Egle Alexander, Harris Alan W, Bouillet Philippe, Cory Suzanne

Abstract excerpt

Impaired apoptosis is now recognized to be central to tumor development. Bcl2, activated by chromosomal translocation in human follicular lymphoma, promotes oncogenesis by inhibiting apoptosis. Bim, a distant proapoptotic relative, is emerging as a major physiologic antagonist of Bcl2. Here, we show that loss of Bim is oncogenic. Bim protein levels were elevated in the apoptosis-prone B lymphoid cells of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15079075
DOI: 10.1073/pnas.0401471101
PMCID: PMC395940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Bim is a suppressor of Myc-induced mouse B cell leukemia.PMID 15079075Read ↗

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