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Article

The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma.

The Journal of biological chemistry - 27 Aug 2010

Lin Jing, Yang Qingyuan, Wilder Paul T, Carrier France, Weber David J

Abstract excerpt

The S100B-p53 protein complex was discovered in C8146A malignant melanoma, but the consequences of this interaction required further study. When S100B expression was inhibited in C8146As by siRNA (siRNA(S100B)), wt p53 mRNA levels were unchanged, but p53 protein, phosphorylated p53, and p53 gene products (i.e. p21 and PIDD) were increased. siRNA(S100B) transfections also restored p53-dependent apoptosis in...

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Identifiers

PMID: 20587415
DOI: 10.1074/jbc.M110.155382
PMCID: PMC2930747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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