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Article

Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase.

Journal of dermatological science - 1 Sept 2006

Yan Hui, Brouha Brook, Liu Tong, Raj Deepak, Biddle Diana, Lee Ray, Grossman Douglas

Abstract excerpt

BACKGROUND: Several inhibitor of apoptosis proteins (IAPs) are cleaved during apoptosis. Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its proteolytic cleavage. OBJECTIVE: To characterize the apoptotic cleavage of Livin in melanocytic cells, and evaluate the role of known proteases. METHODS: We assessed...

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Identifiers

PMID: 16806840
DOI: 10.1016/j.jdermsci.2006.05.007
PMCID: PMC2292408

Genes

TBP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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