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Article

Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells.

PloS one - 1 Jan 2015

Moretti Daniele, Del Bello Barbara, Allavena Giulia, Corti Alessandro, Signorini Cinzia, Maellaro Emilia

Abstract excerpt

Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle. In human melanoma cell lines and biopsies, we previously identified two novel splicing variants (hMp78 and hMp84) of Calpain-3 gene (CAPN3), which have a significant lower expression in vertical growth phase melanomas and, even lower, in metastases, compared to benign nevi. In the...

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Identifiers

PMID: 25658320
DOI: 10.1371/journal.pone.0117258
PMCID: PMC4319969

Genes

CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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