Article
Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK.
The Journal of biological chemistry - 2 May 2014
Hartman Kira G, Vitolo Michele I, Pierce Adam D, Fox Jennifer M, Shapiro Paul, Martin Stuart S, Wilder Paul T, Weber David J
Abstract excerpt
S100B is a prognostic marker for malignant melanoma. Increasing S100B levels are predictive of advancing disease stage, increased recurrence, and low overall survival in malignant melanoma patients. Using S100B overexpression and shRNA(S100B) knockdown studies in melanoma cell lines, elevated S10...
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