Article
CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice.
The Journal of clinical investigation - 1 Dec 2007
Tang Xiuwei, Zhu Yucui, Han Lydia, Kim Arianna L, Kopelovich Levy, Bickers David R, Athar Mohammad
Abstract excerpt
Mutations in the tumor suppressor p53 are detectable in over 50% of all human malignancies. Mutant p53 protein is incapable of transactivating its downstream target genes that are required for DNA repair and apoptosis. Chronic exposure to UVB induces p53 mutations and is carcinogenic in both murine and human skin. CP-31398, a styrylquinazoline compound, restores the tumor suppressor functions of mutant forms of...
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