Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium.

doi:10.1371/journal.pgen.1001002

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Article

Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium.

PLoS genetics - 24 Jun 2010

Long Jirong, Cai Qiuyin, Shu Xiao-Ou, Qu Shimian, Li Chun, Zheng Ying, Gu Kai, Wang Wenjing, Xiang Yong-Bing, Cheng Jiarong, Chen Kexin, Zhang Lina, Zheng Hong, Shen Chen-Yang, Huang Chiun-Sheng, Hou Ming-Feng, Shen Hongbing, Hu Zhibin, Wang Furu, Deming Sandra L, Kelley Mark C, Shrubsole Martha J, Khoo Ui Soon, Chan Kelvin Y K, Chan Sum Yin, Haiman Christopher A, Henderson Brian E, Le Marchand Loic, Iwasaki Motoki, Kasuga Yoshio, Tsugane Shoichiro, Matsuo Keitaro, Tajima Kazuo, Iwata Hiroji, Huang Bo, Shi Jiajun, Li Guoliang, Wen Wanqing, Gao Yu-Tang, Lu Wei, Zheng Wei

Abstract excerpt

Genetic factors play an important role in the etiology of breast cancer. We carried out a multi-stage genome-wide association (GWA) study in over 28,000 cases and controls recruited from 12 studies conducted in Asian and European American women to identify genetic susceptibility loci for breast cancer. After analyzing 684,457 SNPs in 2,073 cases and 2,084 controls in Chinese women, we evaluated 53 SNPs for...

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PMID: 20585626
DOI: 10.1371/journal.pgen.1001002
PMCID: PMC2891809

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