Article
Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.
Nature communications - 5 Mar 2020
Shu Xiang, Long Jirong, Cai Qiuyin, Kweon Sun-Seog, Choi Ji-Yeob, Kubo Michiaki, Park Sue K, Bolla Manjeet K, Dennis Joe, Wang Qin, Yang Yaohua, Shi Jiajun, Guo Xingyi, Li Bingshan, Tao Ran, Aronson Kristan J, Chan Kelvin Y K, Chan Tsun L, Gao Yu-Tang, Hartman Mikael, Kee Ho Weang, Ito Hidemi, Iwasaki Motoki, Iwata Hiroji, John Esther M, Kasuga Yoshio, Soon Khoo Ui, Kim Mi-Kyung, Kong Sun-Young, Kurian Allison W, Kwong Ava, Lee Eun-Sook, Li Jingmei, Lophatananon Artitaya, Low Siew-Kee, Mariapun Shivaani, Matsuda Koichi, Matsuo Keitaro, Muir Kenneth, Noh Dong-Young, Park Boyoung, Park Min-Ho, Shen Chen-Yang, Shin Min-Ho, Spinelli John J, Takahashi Atsushi, Tseng Chiuchen, Tsugane Shoichiro, Wu Anna H, Xiang Yong-Bing, Yamaji Taiki, Zheng Ying, Milne Roger L, Dunning Alison M, Pharoah Paul D P, García-Closas Montserrat, Teo Soo-Hwang, Shu Xiao-Ou, Kang Daehee, Easton Douglas F, Simard Jacques, Zheng Wei
Abstract excerpt
Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential...
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