Article
Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry.
Cancer research - 15 Feb 2011
Cai Qiuyin, Wen Wanqing, Qu Shimian, Li Guoliang, Egan Kathleen M, Chen Kexin, Deming Sandra L, Shen Hongbing, Shen Chen-Yang, Gammon Marilie D, Blot William J, Matsuo Keitaro, Haiman Christopher A, Khoo Ui Soon, Iwasaki Motoki, Santella Regina M, Zhang Lina, Fair Alecia Malin, Hu Zhibin, Wu Pei-Ei, Signorello Lisa B, Titus-Ernstoff Linda, Tajima Kazuo, Henderson Brian E, Chan Kelvin Y K, Kasuga Yoshio, Newcomb Polly A, Zheng Hong, Cui Yong, Wang Furu, Shieh Ya-Lan, Iwata Hiroji, Le Marchand Loic, Chan Sum Yin, Shrubsole Martha J, Trentham-Dietz Amy, Tsugane Shoichiro, Garcia-Closas Montserrat, Long Jirong, Li Chun, Shi Jiajun, Huang Bo, Xiang Yong-Bing, Gao Yu-Tang, Lu Wei, Shu Xiao-Ou, Zheng Wei
Abstract excerpt
We evaluated the generalizability of a single nucleotide polymorphism (SNP), rs2046210 (A/G allele), associated with breast cancer risk that was initially identified at 6q25.1 in a genome-wide association study conducted among Chinese women. In a pooled analysis of more than 31,000 women of East-Asian, European, and African ancestry, we found a positive association for rs2046210 and breast cancer risk in Chinese...