Article
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.
Nature genetics - 1 Aug 2014
Cai Qiuyin, Zhang Ben, Sung Hyuna, Low Siew-Kee, Kweon Sun-Seog, Lu Wei, Shi Jiajun, Long Jirong, Wen Wanqing, Choi Ji-Yeob, Noh Dong-Young, Shen Chen-Yang, Matsuo Keitaro, Teo Soo-Hwang, Kim Mi Kyung, Khoo Ui Soon, Iwasaki Motoki, Hartman Mikael, Takahashi Atsushi, Ashikawa Kyota, Matsuda Koichi, Shin Min-Ho, Park Min Ho, Zheng Ying, Xiang Yong-Bing, Ji Bu-Tian, Park Sue K, Wu Pei-Ei, Hsiung Chia-Ni, Ito Hidemi, Kasuga Yoshio, Kang Peter, Mariapun Shivaani, Ahn Sei Hyun, Kang Han Sung, Chan Kelvin Y K, Man Ellen P S, Iwata Hiroji, Tsugane Shoichiro, Miao Hui, Liao Jiemin, Nakamura Yusuke, Kubo Michiaki, Delahanty Ryan J, Zhang Yanfeng, Li Bingshan, Li Chun, Gao Yu-Tang, Shu Xiao-Ou, Kang Daehee, Zheng Wei
Abstract excerpt
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)). We replicated these...