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Article

Tetherin Restricts Productive HIV-1 Cell-to-Cell Transmission

17 Jun 2010

Abstract excerpt

The IFN-inducible antiviral protein tetherin (or BST-2/CD317/HM1.24) impairs release of mature HIV-1 particles from infected cells. HIV-1 Vpu antagonizes the effect of tetherin. The fate of virions trapped at the cell surface remains poorly understood. Here, we asked whether tetherin impairs HIV cell-to-cell transmission, a major means of viral spread. Tetherin-positive or -negative cells, infected with wild-type...

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PMID: 20585562
DOI: 10.1371/journal.ppat.1000955

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Research trail→

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Tetherin Restricts Productive HIV-1 Cell-to-Cell TransmissionPMID 20585562Read ↗

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