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Article

Tetherin and Its Viral Antagonists

10 Jan 2011

Abstract excerpt

Restriction factors comprise an important layer of host defense to fight against viral infection. Some restriction factors are constitutively expressed whereas the majority is induced by interferon to elicit innate immunity. In addition to a number of well-characterized interferon-inducible antiviral factors such as RNaseL/OAS, ISG15, Mx, PKR, and ADAR, tetherin (BST-2/CD317/HM1.24) was recently discovered to...

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PMID: 21222046
DOI: 10.1007/s11481-010-9256-1

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