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Article

Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-specific differences in ventricular refractoriness and His conduction.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2010

Odening Katja E, Kirk Malcolm, Brunner Michael, Ziv Ohad, Lorvidhaya Peem, Liu Gong Xin, Schofield Lorraine, Chaves Leonard, Peng Xuwen, Zehender Manfred, Choi Bum-Rak, Koren Gideon

Abstract excerpt

We have generated transgenic rabbits lacking cardiac slow delayed-rectifier K(+) current [I(Ks); long QT syndrome type 1 (LQT1)] or rapidly activating delayed-rectifier K(+) current [I(Kr); long QT syndrome type 2 (LQT2)]. Rabbits with either genotype have prolonged action potential duration and QT intervals; however, only LQT2 rabbits develop atrioventricular (AV) blocks and polymorphic ventricular tachycardia....

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Identifiers

PMID: 20581090
DOI: 10.1152/ajpheart.00074.2010
PMCID: PMC2944497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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