Article
Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts.
Acta physiologica (Oxford, England) - 1 Jul 2015
Salvage S C, King J H, Chandrasekharan K H, Jafferji D I G, Guzadhur L, Matthews H R, Huang C L-H, Fraser J A
Abstract excerpt
AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation. Recent work associates reduced atrial Nav 1.5 currents in homozygous RyR2-P2328S (RyR2(S/S) ) mice with slowed conduction and increased arrhythmogenicity. Yet clinically, and in murine models, the Nav 1.5 blocker...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.