Article
Distinct gene-specific mechanisms of arrhythmia revealed by cardiac gene transfer of two long QT disease genes, HERG and KCNE1.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2001
Hoppe U C, Marbán E, Johns D C
Abstract excerpt
The long QT syndrome (LQTS) is a heritable disorder that predisposes to sudden cardiac death. LQTS is caused by mutations in ion channel genes including HERG and KCNE1, but the precise mechanisms remain unclear. To clarify this situation we injected adenoviral vectors expressing wild-type or LQT mutants of HERG and KCNE1 into guinea pig myocardium. End points at 48-72 h included electrophysiology in isolated...
Topics
- Action Potentials
- Adenoviridae
- Animals
- Cation Transport Proteins
- Death, Sudden, Cardiac
- Disease Models, Animal
- Electric Conductivity
- Electrocardiography
- Ether-A-Go-Go Potassium Channels
- Gene Transfer Techniques
- Genetic Vectors
- Guinea Pigs
- Heart Rate