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Article

A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene.

British journal of pharmacology - 1 Jun 2016

Major Péter, Baczkó István, Hiripi László, Odening Katja E, Juhász Viktor, Kohajda Zsófia, Horváth András, Seprényi György, Kovács Mária, Virág László, Jost Norbert, Prorok János, Ördög Balázs, Doleschall Zoltán, Nattel Stanley, Varró András, Bősze Zsuzsanna

Abstract excerpt

BACKGROUND AND PURPOSE: The reliable assessment of proarrhythmic risk of compounds under development remains an elusive goal. Current safety guidelines focus on the effects of blocking the KCNH2/HERG ion channel-in tissues and animals with intact repolarization. Novel models with better predictive value are needed that more closely reflect the conditions in patients with cardiac remodelling and reduced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27076034
DOI: 10.1111/bph.13500
PMCID: PMC4882500

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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