Article
Transient Outward K+ Current (Ito) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long-QT Syndrome Type 1.
Circulation. Arrhythmia and electrophysiology - 1 Jun 2018
Choi Bum-Rak, Li Weiyan, Terentyev Dmitry, Kabakov Anatoli Y, Zhong Mingwang, Rees Colin M, Terentyeva Radmila, Kim Tae Yun, Qu Zhilin, Peng Xuwen, Karma Alain, Koren Gideon
Abstract excerpt
BACKGROUND: Sudden death in long-QT syndrome type 1 (LQT1), an inherited disease caused by loss-of-function mutations in KCNQ1, is triggered by early afterdepolarizations (EADs) that initiate polymorphic ventricular tachycardia (pVT). We investigated ionic mechanisms that underlie pVT in LQT1 using a transgenic rabbit model of LQT1. METHODS: Optical mapping, cellular patch clamping, and computer modeling were...
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