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Article

Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits.

The Journal of physiology - 1 Mar 2012

Liu Gong-Xin, Choi Bum-Rak, Ziv Ohad, Li Weiyan, de Lange Enno, Qu Zhilin, Koren Gideon

Abstract excerpt

Early after-depolarization (EAD), or abnormal depolarization during the plateau phase of action potentials, is a hallmark of long-QT syndrome (LQTS). More than 13 genes have been identified as responsible for LQTS, and elevated risks for EADs may depend on genotypes, such as exercise in LQT1 vs. sudden arousal in LQT2 patients. We investigated mechanisms underlying different high-risk conditions that trigger EADs...

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Identifiers

PMID: 22183728
DOI: 10.1113/jphysiol.2011.218164
PMCID: PMC3381823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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