Article

Knock-in <i>Kcnh2</i> Rabbit Model of Long QT Syndrome Type-2, Epilepsy, and Sudden Death

2024-12-16

Abstract excerpt

<h4>Background</h4> Long QT Syndrome Type-2 (LQT2) is due to loss-of-function KCNH2 variants. KCNH2 encodes K v 11.1 that forms a delayed-rectifier potassium channel in the brain and heart. LQT2 is associated with arrhythmias, seizures, sudden cardiac death, and sudden unexpected death in epilepsy (SUDEP). The goal of the study is to develop a translational model that reproduces the neuro-cardiac electrical ab...

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Literature Corpus work: 3c6cf22b-3d17-5aa2-8338-b3590d1fe3d6
DOI: 10.1101/2024.12.11.627988

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