Article
Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice.
The Journal of physiology - 15 Aug 2010
Izbeki Ferenc, Asuzu David T, Lorincz Andrea, Bardsley Michael R, Popko Laura N, Choi Kyoung Moo, Young David L, Hayashi Yujiro, Linden David R, Kuro-o Makoto, Farrugia Gianrico, Ordog Tamas
Abstract excerpt
Gastrointestinal functions decline with ageing leading to impaired quality of life, and increased morbidity and mortality. Neurodegeneration is believed to underlie ageing-associated dysmotilities but the mechanisms have not been fully elucidated. We used progeric mice deficient in the anti-ageing peptide Klotho to investigate the contribution of key cell types of the gastric musculature to ageing-associated...
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