Kit mutants and gastrointestinal physiology.

doi:10.1113/jphysiol.2006.122473

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Article

Kit mutants and gastrointestinal physiology.

The Journal of physiology - 1 Jan 2007

Sanders Kenton M, Ward Sean M

Abstract excerpt

There has been considerable speculation about the function of interstitial cells of Cajal (ICC) since their discovery more than 100 years ago. It has been difficult to study these cells under native conditions, but great insights about the function of ICC have come from studies of genetic models with loss-of function mutations in the Kit signalling pathway. First it was discovered that signalling via Kit (a...

Topics

Animals
Biological Clocks
Enteric Nervous System
Gastrointestinal Tract
Humans
Motor Neurons
Mutation
Parasympathetic Nervous System
Proto-Oncogene Proteins c-kit

Source

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Identifiers

PMID: 17095561
DOI: 10.1113/jphysiol.2006.122473
PMCID: PMC2075131

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