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Article

Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system.

Gut - 1 May 2018

Becker Laren, Nguyen Linh, Gill Jaspreet, Kulkarni Subhash, Pasricha Pankaj Jay, Habtezion Aida

Abstract excerpt

OBJECTIVE: The enteric nervous system (ENS) undergoes neuronal loss and degenerative changes with age. The cause of this neurodegeneration is poorly understood. Muscularis macrophages residing in close proximity to enteric ganglia maintain neuromuscular function via direct crosstalk with enteric neurons and have been implicated in the pathogenesis of GI motility disorders like gastroparesis and postoperative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28228489
DOI: 10.1136/gutjnl-2016-312940
PMCID: PMC5565713

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