Article
Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. elegans.
Current biology : CB - 27 Jul 2010
Brenner John L, Jasiewicz Kristen L, Fahley Alisha F, Kemp Benedict J, Abbott Allison L
Abstract excerpt
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate the translation and/or stability of their mRNA targets. Previous work showed that for most miRNA genes of C. elegans, single-gene knockouts did not result in detectable mutant phenotypes. This may be due, in part, to functional redundancy between miRNAs. However, in most cases, worms carrying deletions of all members of a miRNA family do not display...
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