[Genetic alterations in MAPK and PI3K/Akt signaling pathways and the generation, progression, diagnosis and therapy of thyroid cancer].

Abstract excerpt

The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and phoshoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathways play a major role in regulating cell growth, proliferation and apoptosis, via transmission of cell signals to cell nucleus. The genes, coding the MAPK/ERK and PI3K/Akt signaling cascade proteins, are significantly mutated in thyroid cancer. Genetic...

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