Article
Oncogenic mutations in the TP53 and PI-3 kinase/AKT pathway are independent predictors of survival for advanced thyroid cancer: Analysis from the Molecular Screening and Therapeutics (MoST) program.
Surgery - 1 Jan 2025
Novis Elan, Glover Anthony, Grady John P, Silvestri Audrey, Thavaneswaran Subotheni, Lin Frank, Ballinger Mandy L, Thomas David M
Abstract excerpt
BACKGROUND: Thyroid cancers with mutations in the phosphatidylinositol-3 kinase/AKT pathway have a poorer prognosis. However, knowledge about the relationship between histology, mutation profile, and outcomes is still developing. This study assessed the prognostic value of genomic profiles for patients with advanced thyroid cancer who experienced progression on conventional treatment. METHODS: Patients recruited...
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