Article
Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Feb 2008
Juran Brian D, Atkinson Elizabeth J, Schlicht Erik M, Fridley Brooke L, Petersen Gloria M, Lazaridis Konstantinos N
Abstract excerpt
UNLABELLED: Autoimmune diseases such as primary biliary cirrhosis (PBC) result from failure in the immune mechanisms that establish and maintain self-tolerance. Evidence suggests that these processes are shared among the spectrum of autoimmune syndromes and are likely genetically determined. Cytotoxic T-lymphocyte antigen 4 (CTLA4) and programmed cell-death 1 (PDCD1) are two genes encoding coinhibitory...
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