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Article

Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.

Gastroenterology - 1 Oct 2008

Juran Brian D, Atkinson Elizabeth J, Schlicht Erik M, Fridley Brooke L, Lazaridis Konstantinos N

Abstract excerpt

BACKGROUND & AIMS: Genetic variation is invoked as a strong component underlying primary biliary cirrhosis (PBC) and other autoimmune disorders. Data suggest that some of this genetic risk is shared, affecting function of the immune mechanisms controlling self-tolerance. Cytotoxic T-lymphocyte antigen 4 (CTLA4) encodes a coinhibitory immunoreceptor that is a key regulator of self-tolerance with established...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, CD

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Source

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Identifiers

PMID: 18778710
DOI: 10.1053/j.gastro.2008.06.077
PMCID: PMC2613835

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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