Article
Compensatory mutations restore fitness during the evolution of dihydrofolate reductase.
Molecular biology and evolution - 1 Dec 2010
Brown Kyle M, Costanzo Marna S, Xu Wenxin, Roy Scott, Lozovsky Elena R, Hartl Daniel L
Abstract excerpt
Whether a trade-off exists between robustness and evolvability is an important issue for protein evolution. Although traditional viewpoints have assumed that existing functions must be compromised by the evolution of novel activities, recent research has suggested that existing phenotypes can be robust to the evolution of novel protein functions. Enzymes that are targets of antibiotics that are competitive...
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