Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs.

Abstract excerpt

There is growing interest in designing multidrug therapies that leverage tradeoffs to combat resistance. Tradeoffs are common in evolution and occur when, for example, resistance to one drug results in sensitivity to another. Major questions remain about the extent to which tradeoffs are reliable, specifically, whether the mutants that provide resistance to a given drug all suffer similar tradeoffs. This question...

Topics

• Fluconazole
• Mutation
• Saccharomyces cerevisiae
• Genetic Fitness
• Antifungal Agents
• Drug Resistance, Fungal