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Article

The evolutionary landscape of antifolate resistance in Plasmodium falciparum.

Journal of genetics - 1 Aug 2011

Costanzo Marna S, Hartl Daniel L

Abstract excerpt

Resistance to antifolates in Plasmodium falciparum is well described and has been observed in clinical settings for decades. At the molecular level, point mutations in the dhfr gene that lead to resistance have been identified, and the crystal structure of the wildtype and mutant dihydrofolate reductase enzymes have been solved in complex with native substrate and drugs. However, we are only beginning to...

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Identifiers

PMID: 21869466
DOI: 10.1007/s12041-011-0072-z
PMCID: PMC3212943

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