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Article

Accessible mutational trajectories for the evolution of pyrimethamine resistance in the malaria parasite Plasmodium vivax.

Journal of molecular evolution - 1 Sept 2013

Jiang Pan-Pan, Corbett-Detig Russell B, Hartl Daniel L, Lozovsky Elena R

Abstract excerpt

Antifolate antimalarials, such as pyrimethamine, have experienced a dramatic reduction in therapeutic efficacy as resistance has evolved in multiple malaria species. We present evidence from one such species, Plasmodium vivax, which has experienced sustained selection for pyrimethamine resistance at the dihydrofolate reductase (DHFR) locus since the 1970s. Using a transgenic Saccharomyces cerevisiae model...

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Identifiers

PMID: 24071997
DOI: 10.1007/s00239-013-9582-z

Genes

DHFR

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