Article
The impact of antimalarial drug resistance mutations on parasite fitness, and its implications for the evolution of resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jan 2000
Hastings Ian M, Donnelly Martin J
Abstract excerpt
It is widely assumed in genetics that most mutations disrupt metabolism to some extent, and are consequently likely to be disadvantageous for the organisms that inherit them. This may apply to mutations encoding drug resistance in malaria, where the mutation may be disadvantageous in the absence...
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